Prasad S Dhurjati
- Joint Professor, Mathematical Sciences
- Full Professor
University of Delaware
Newark, Delaware 19716
- Doctorate - 1982 Purdue University
- Bachelors - 1977 Indian Institute of Technology, Kanpur, India
"Our current research combines three decades of expertise in biotechnology and artificial intelligence. This research has resulted in over a hundred publications that have been cited more than 2800 times with a H-index of 28 and an i10 index of 50. The top five papers have been cited over 1000 times. The research has also resulted in the training of nearly 40 graduate students and post-doctoral research fellows (who are currently well placed in industry and academia) and over 100 undergraduate research students. Current research is in the area of Systems Biology, Systems Medicine and Modeling of Engineering Systems. In biotechnology, we are currently applying mathematical models and knowledge-based approaches to convert biological and medical data to useful knowledge.
Our past research in biotechnology has resulted in a better understanding of microscopic and macroscopic variables that influence the kinetics of genetically engineered microorganisms. The work from 1977 to 2000 in biochemical engineering was largely experimental. In joint research with the Pasteur Institute in Paris, we examined the effect of gene sequence and protein structure on the mechanism of inclusion body (protein aggregate) formation during high-level expression of cellulolytic proteins in recombinant cells. As part of collaborative research with DuPont in environmental biotechnology, we investigated the use of bioluminescent recombinant microorganisms as sensors for pollutants.
A second major area of our research is Knowledge-Based Process Monitoring and Fault Diagnosis. In a joint project with Foxboro and DuPont (1982-86), we were involved in a pioneering effort for the first industrial application of an expert system, FALCON (Fault Analysis Consultant), for on-line fault diagnosis in a dynamic chemical process (DuPont adipic acid plant in Victoria, Texas).
Another area of research activity is in the Biotransformation of Coal to Methane using a community of microorganisms. We are examining the kinetics of biodegradation of coal using lumped kinetic models and experiments with lab-scale reactors. These models and experiments will assist us in improving commercial scale Coal Bed Methane (CBM) processes via microbial enhancement.
We are currently combining our past expertise in biotechnology and knowledge-based systems to examine novel applications in Systems Biology and Systems Medicine. A major area of focus is the relationship between the gut microbiome and imbalances in the physiological system. In the area of Systems Medicine, we are looking at the effect of the human microbiome on health and diseases. We have recently developed a systems connectivity model of Autism Spectrum Disorders (ASD) and also followed up with mathematical models and artificial intelligence or agent-based models of ASD. Our goal is to develop system level models and tools for analysis and integration of information at various levels of hierarchy in biological and medical systems. We have also developed Physiology-Based PharmacoKinetic (PBPK) models to understand the distribution of various drugs in the human body including calculating dosages for nanoparticle delivery in leukemia therapy, dosages for osteoporosis, and for lithium in bipolar disorder. Our review article on Systems Biology (April 2008) points to the future direction of our research."
- Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "A Cybernetic View of Microbial Growth: Modeling of Cells as Optimal Strategists", Biotechnology and Bioengineering 27, 1, (1985)
- Petti, T. F., J. Klein and P. Dhurjati, "The Diagnostic Model Processor - Using Deep Knowledge for Process Fault Diagnosis", AIChE Journal 36 (4), 565, (1990)
- Van Dyk, Tina K., W. R. Majarian, K. B. Konstantinov, R. M. Young, P. Dhurjati and R. LaRossa, "Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions", Applied and Environmental Microbiology 60 (5), 1414, (1994)
- S. Saldanha, B. Bragdon, O. Moseychuk, J. Bonor, P. Dhurjati, A. Nohe,, "Caveolae Regulate Smad Signaling as Verified by Novel Imaging and System Biology Apporaches", Journal of Cell Physiology 228, 1060, (2013)
- Colin Heberling, Prasad Dhurjati and Myron Sasser, "Hypothesis for a systems connectivity model of autism spectral disorder pathogenesis: Link to gut bacteria, oxidative stress and intestinal permeability", Medical Hypotheses 80, 264, (2013)
- Sean G. Mack, Daniel J. Cook, Prasad Dhurjati, Matthew E. R. Butchbach, "Systems Biology Investigation of cAMP Modulation to increase SMN levels for the Treatment of Spinal Muscular Atrophy", PLOS One 9(12), (2014)
- Ryan Downs, Jonathon Perna, Andrew Vitelli, Daniel Cook, Prasad Dhurjati, "Model-based hypothesis of gut-microbe populations and gut/brain barrier permeabilities in the development of regressive autism", Medical Hypotheses 83, 649, (2014)
- MJ Gilkey, V. Krishan, L. Scheetz, X Jia, AK Rajasekaran, PS Dhurjati, "Physiologically Based Pharmacokinetic Modeling of Fluorescently Lableled Block Copolymer Nanoparticles for Controlled Drug Delivery in Leukemia Therapy", CPT Pharmacometrics and Systems Pharmacology 4(3), 167, (2015)
- Bronson Weston, Benjamin Fogal, Daniel Cook, Prasad Dhurjati, "An agent-based modeling framework for evaluating hypotheses on risks for developing autism: Effects of the gut microbial environment", Medical Hypotheses (2015)
- A. Lisberg, R. Ellis, K. Nicholson, P. Moku, A. Swarup, P. Dhurjati, A. Nohe, "Mathematical Modeling of the Effects of CK2.3 on Mineralization in Osteoporotic Bone", CPT Pharmacometrics & Systems Pharmacology 6, 208, (2017)
- NSF Presidential Young Investigator Award: 1986 - 1991
- College of Engineering Special Faculty Award
- Elected Fellow, American Institute of Medical and Biological Engineering